Numerical modeling for in vivo electroporation.

Evaluation of Soft Tissue Sarcoma Tumors Electrical Conductivity Anisotropy Using Diffusion Tensor Imaging for Numerical Modeling on Electroporation

Introduction: There is many ways to assessing the electrical conductivity anisotropyof a tumor. Applying the values of tissue electrical conductivity anisotropyis crucial in numerical modeling of the electric and thermal field distribution in electroporationtreatments. This study aims to calculate the tissues electrical conductivityanisotropy in patients with sarcoma tumors using diffusion tens...

Numerical modeling in electroporation-based biomedical applications

Background. Numerous experiments have to be performed before a biomedical application is put to practical use in clinical environment. As a complementary work to in vitro, in vivo and medical experiments, we can use analytical and numerical models to represent, as realistically as possible, real biological phenomena of, in our case, electroporation. In this way we can evaluate different electri...

A Multi Objective Genetic Algorithm (MOGA) for Optimizing Thermal and Electrical Distribution in Tumor Ablation by Irreversible Electroporation

Background: Irreversible electroporation (IRE) is a novel tumor ablation technique. IRE is associated with high electrical fields and is often reported in conjunction with thermal damage caused by Joule heating. For good response to surgery it is crucial to produce minimum thermal damage in both tumoral and healthy tissues named Non-Thermal Irreversible Electroporation(NTIRE). Non-thermal irrev...

Modeling of electric field distribution in tissues during electroporation

BACKGROUND Electroporation based therapies and treatments (e.g. electrochemotherapy, gene electrotransfer for gene therapy and DNA vaccination, tissue ablation with irreversible electroporation and transdermal drug delivery) require a precise prediction of the therapy or treatment outcome by a personalized treatment planning procedure. Numerical modeling of local electric field distribution wit...

Optimization and Numerical Modeling in Irreversible Electroporation Treatment Planning

Ex Vivo and In Silico Feasibility Study of Monitoring Electric Field Distribution in Tissue during Electroporation Based Treatments

Magnetic resonance electrical impedance tomography (MREIT) was recently proposed for determining electric field distribution during electroporation in which cell membrane permeability is temporary increased by application of an external high electric field. The method was already successfully applied for reconstruction of electric field distribution in agar phantoms. Before the next step toward...